| Pitching | ||||||
| Name | yrs | |||||
| Roger Clemens | 22 | |||||
| Greg Maddux | 21 | |||||
| Nolan Ryan | 21 | |||||
| Eppa Rixey | 21 | |||||
| Herb Pennock | 21 | |||||
| Mike Stanton | 21 | |||||
| Name | W | Name | L | |||
| Walter Johnson | 489 | Grover Cleveland Alexander | 226 | |||
| Roger Clemens | 416 | Nolan Ryan | 225 | |||
| Greg Maddux | 380 | Red Faber | 221 | |||
| Red Ruffing | 358 | Tom Glavine | 218 | |||
| Randy Johnson | 325 | Eppa Rixey | 213 | |||
| Grover Cleveland Alexander | 275 | Jim Kaat | 199 | |||
| Nolan Ryan | 272 | Burleigh Grimes | 198 | |||
| Eppa Rixey | 256 | Freddie Fitzsimmons | 197 | |||
| Ted Lyons | 251 | Tommy John | 196 | |||
| Pedro J. Martinez | 245 | Bob Welch | 189 | |||
| Name | S | Name | G | |||
| Trevor Hoffman | 425 | John Franco | 880 | |||
| Mariano Rivera | 348 | Hoyt Wilhelm | 867 | |||
| Hoyt Wilhelm | 326 | Lee Smith | 818 | |||
| Lee Smith | 283 | Mike Stanton | 789 | |||
| Jeff Montgomery | 261 | Mike Jackson | 761 | |||
| Ron Perranoski | 256 | Jesse Orosco | 758 | |||
| Tom Henke | 246 | Dan Plesac | 752 | |||
| Ted Abernathy | 235 | Trevor Hoffman | 729 | |||
| Roberto Hernandez | 235 | Mike Timlin | 725 | |||
| Robb Nen | 230 | Dennis Eckersley | 702 | |||
| Todd Worrell | 230 | |||||
| Name | GS | Name | CG | |||
| Roger Clemens | 682 | Walter Johnson | 410 | |||
| Greg Maddux | 647 | Red Ruffing | 334 | |||
| Tom Glavine | 611 | Grover Cleveland Alexander | 290 | |||
| Nolan Ryan | 575 | Greg Maddux | 281 | |||
| Grover Cleveland Alexander | 572 | Nolan Ryan | 251 | |||
| Randy Johnson | 563 | Ted Lyons | 251 | |||
| Eppa Rixey | 553 | Red Faber | 226 | |||
| Red Ruffing | 539 | Warren Spahn | 224 | |||
| Don Sutton | 532 | Eppa Rixey | 223 | |||
| Walter Johnson | 507 | Wilbur Cooper | 219 | |||
| Name | SHO | Name | IP | |||
| Walter Johnson | 78 | Greg Maddux | 5085.7 | |||
| Greg Maddux | 67 | Roger Clemens | 5080.6 | |||
| Nolan Ryan | 56 | Walter Johnson | 4717.6 | |||
| Roger Clemens | 51 | Grover Cleveland Alexander | 4684.6 | |||
| Pedro J. Martinez | 47 | Nolan Ryan | 4545.1 | |||
| Randy Johnson | 46 | Red Ruffing | 4400.7 | |||
| Grover Cleveland Alexander | 42 | Eppa Rixey | 4265.2 | |||
| Bob Gibson | 42 | Tom Glavine | 4264.1 | |||
| Dennis Martinez | 41 | Randy Johnson | 4243.4 | |||
| Don Sutton | 3897.8 | |||||
| Name | H | Name | R | |||
| Grover Cleveland Alexander | 4887 | Eppa Rixey | 2287 | |||
| Greg Maddux | 4663 | Grover Cleveland Alexander | 2257 | |||
| Tom Glavine | 4561 | Tom Glavine | 2241 | |||
| Eppa Rixey | 4540 | Red Ruffing | 2082 | |||
| Red Ruffing | 4463 | Sam Jones | 1995 | |||
| Roger Clemens | 4323 | Red Faber | 1971 | |||
| Herb Pennock | 3894 | Burleigh Grimes | 1969 | |||
| Sam Jones | 3880 | Herb Pennock | 1967 | |||
| Red Faber | 3869 | Roger Clemens | 1936 | |||
| Waite Hoyt | 3796 | Waite Hoyt | 1924 | |||
| Name | ER | Name | HR | |||
| Tom Glavine | 2011 | Don Sutton | 442 | |||
| Grover Cleveland Alexander | 1793 | Jack Morris | 437 | |||
| Eppa Rixey | 1792 | Curt Schilling | 425 | |||
| Roger Clemens | 1753 | Randy Johnson | 418 | |||
| Red Ruffing | 1748 | Tom Glavine | 415 | |||
| Greg Maddux | 1719 | Roger Clemens | 404 | |||
| Nolan Ryan | 1634 | Jamie Moyer | 402 | |||
| Burleigh Grimes | 1625 | Mike Mussina | 400 | |||
| Red Faber | 1590 | Bill Gullickson | 399 | |||
| Waite Hoyt | 1578 | David Wells | 388 | |||
| Name | BB | Name | K | |||
| Nolan Ryan | 2276 | Randy Johnson | 4872 | |||
| Roger Clemens | 1692 | Roger Clemens | 4588 | |||
| Randy Johnson | 1560 | Nolan Ryan | 4571 | |||
| Red Ruffing | 1556 | Greg Maddux | 3360 | |||
| Tom Glavine | 1509 | Curt Schilling | 3168 | |||
| Eppa Rixey | 1447 | Pedro J. Martinez | 3124 | |||
| Sam Jones | 1394 | Steve Carlton | 2880 | |||
| Mark Langston | 1393 | John Smoltz | 2825 | |||
| Bob Feller | 1367 | Mike Mussina | 2795 | |||
| Chuck Finley | 1356 | Walter Johnson | 2759 | |||
| Name | ERA | Name | W | L | PCT | |
| Walter Johnson | 2.01 | Walter Johnson | 489 | 63 | .886 | |
| Sandy Koufax | 2.34 | Sandy Koufax | 164 | 46 | .781 | |
| Babe Ruth | 2.51 | Roger Clemens | 416 | 148 | .738 | |
| Reb Russell | 2.52 | Pedro J. Martinez | 245 | 88 | .736 | |
| Larry Cheney | 2.60 | Red Ruffing | 358 | 129 | .735 | |
| Jack Coombs | 2.68 | Tim Hudson | 150 | 61 | .711 | |
| Pedro J. Martinez | 2.75 | Randy Johnson | 325 | 139 | .700 | |
| Lee Smith | 2.76 | Kevin Appier | 200 | 86 | .699 | |
| Eddie Fisher | 2.81 | Teddy Higuera | 102 | 44 | .699 | |
| Carl Weilman | 2.85 | Gary Nolan | 74 | 32 | .698 |